1di2: Difference between revisions

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{{Seed}}
[[Image:1di2.png|left|200px]]


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==CRYSTAL STRUCTURE OF A DSRNA-BINDING DOMAIN COMPLEXED WITH DSRNA: MOLECULAR BASIS OF DOUBLE-STRANDED RNA-PROTEIN INTERACTIONS==
The line below this paragraph, containing "STRUCTURE_1di2", creates the "Structure Box" on the page.
<StructureSection load='1di2' size='340' side='right'caption='[[1di2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1di2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DI2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1di2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1di2 OCA], [https://pdbe.org/1di2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1di2 RCSB], [https://www.ebi.ac.uk/pdbsum/1di2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1di2 ProSAT]</span></td></tr>
{{STRUCTURE_1di2| PDB=1di2 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRKAB_XENLA PRKAB_XENLA] Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/1di2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1di2 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF A DSRNA-BINDING DOMAIN COMPLEXED WITH DSRNA: MOLECULAR BASIS OF DOUBLE-STRANDED RNA-PROTEIN INTERACTIONS===
==See Also==
 
*[[P19|P19]]
 
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_9857205}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9857205 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9857205}}
 
==About this Structure==
1DI2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DI2 OCA].
 
==Reference==
Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA., Ryter JM, Schultz SC, EMBO J. 1998 Dec 15;17(24):7505-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9857205 9857205]
[[Category: Single protein]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Ryter, J M.]]
[[Category: Ryter JM]]
[[Category: Schultz, S C.]]
[[Category: Schultz SC]]
[[Category: Double stranded rna]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna interaction]]
[[Category: Rna-bining protein]]
 
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Retrieved from "https://proteopedia.org/1di2"