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{{Seed}}
[[Image:1dli.png|left|200px]]


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==THE FIRST STRUCTURE OF UDP-GLUCOSE DEHYDROGENASE (UDPGDH) REVEALS THE CATALYTIC RESIDUES NECESSARY FOR THE TWO-FOLD OXIDATION==
The line below this paragraph, containing "STRUCTURE_1dli", creates the "Structure Box" on the page.
<StructureSection load='1dli' size='340' side='right'caption='[[1dli]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDX:URIDINE-5-DIPHOSPHATE-XYLOPYRANOSE'>UDX</scene></td></tr>
{{STRUCTURE_1dli|  PDB=1dli  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dli OCA], [https://pdbe.org/1dli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dli RCSB], [https://www.ebi.ac.uk/pdbsum/1dli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dli ProSAT]</span></td></tr>
 
</table>
===THE FIRST STRUCTURE OF UDP-GLUCOSE DEHYDROGENASE (UDPGDH) REVEALS THE CATALYTIC RESIDUES NECESSARY FOR THE TWO-FOLD OXIDATION===
== Function ==
 
[https://www.uniprot.org/uniprot/UDG_STRPY UDG_STRPY] Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_10841783}}, adds the Publication Abstract to the page
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dli_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_10841783}}
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==About this Structure==
  </jmolCheckbox>
1DLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLI OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dli ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation., Campbell RE, Mosimann SC, van De Rijn I, Tanner ME, Strynadka NC, Biochemistry. 2000 Jun 13;39(23):7012-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10841783 10841783]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
[[Category: UDP-glucose 6-dehydrogenase]]
[[Category: Campbell RE]]
[[Category: Campbell, R E.]]
[[Category: Mosimann SC]]
[[Category: Mosimann, S C.]]
[[Category: Strynadka NCJ]]
[[Category: Rijn, I van de.]]
[[Category: Tanner ME]]
[[Category: Strynadka, N C.J.]]
[[Category: Van de Rijn I]]
[[Category: Tanner, M E.]]
[[Category: Crystallographic dimer]]
[[Category: Rossmann fold]]
[[Category: Ternary complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:15:13 2008''

Latest revision as of 06:55, 7 February 2024

THE FIRST STRUCTURE OF UDP-GLUCOSE DEHYDROGENASE (UDPGDH) REVEALS THE CATALYTIC RESIDUES NECESSARY FOR THE TWO-FOLD OXIDATION

1dli, resolution 2.31Å

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