1doh: Difference between revisions

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{{Seed}}
[[Image:1doh.png|left|200px]]


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==STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND 4-NITRO-INDEN-1-ONE==
The line below this paragraph, containing "STRUCTURE_1doh", creates the "Structure Box" on the page.
<StructureSection load='1doh' size='340' side='right'caption='[[1doh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1doh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyricularia_grisea Pyricularia grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DOH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=NID:4-NITRO-INDEN-1-ONE'>NID</scene></td></tr>
{{STRUCTURE_1doh|  PDB=1doh  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1doh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1doh OCA], [https://pdbe.org/1doh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1doh RCSB], [https://www.ebi.ac.uk/pdbsum/1doh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1doh ProSAT]</span></td></tr>
 
</table>
===STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND 4-NITRO-INDEN-1-ONE===
== Function ==
 
[https://www.uniprot.org/uniprot/T4HR_MAGO7 T4HR_MAGO7] Catalyzes the NADPH-dependent reduction of 1,3,6,8-tetrahydroxynaphthalene (T4HN) into (+)-scytalone and 1,3,8-trihydroxynaphthalene into (-)-vermelone. This enzyme is the biochemical target of several commercially important fungicides which are used to prevent blast disease in rice plants.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/1doh_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_11342131}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1DOH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Magnaporthe_grisea Magnaporthe grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOH OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1doh ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis., Liao D, Basarab GS, Gatenby AA, Valent B, Jordan DB, Structure. 2001 Jan 10;9(1):19-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11342131 11342131]
</StructureSection>
[[Category: Magnaporthe grisea]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Pyricularia grisea]]
[[Category: Tetrahydroxynaphthalene reductase]]
[[Category: Basarab GS]]
[[Category: Basarab, G S.]]
[[Category: Gatenby AA]]
[[Category: Gatenby, A A.]]
[[Category: Jordan DB]]
[[Category: Jordan, D B.]]
[[Category: Liao DI]]
[[Category: Liao, D I.]]
[[Category: Dinucleotide binding fold]]
[[Category: Protein-nadph-active site inhibitor complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:22:47 2008''
Retrieved from "https://proteopedia.org/1doh"