1e6f: Difference between revisions

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{{Seed}}
[[Image:1e6f.png|left|200px]]


<!--
==Human MIR-receptor, repeat 11==
The line below this paragraph, containing "STRUCTURE_1e6f", creates the "Structure Box" on the page.
<StructureSection load='1e6f' size='340' side='right'caption='[[1e6f]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1e6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E6F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e6f OCA], [https://pdbe.org/1e6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e6f RCSB], [https://www.ebi.ac.uk/pdbsum/1e6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e6f ProSAT]</span></td></tr>
{{STRUCTURE_1e6f| PDB=1e6f |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/1e6f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e6f ConSurf].
<div style="clear:both"></div>


===HUMAN MIR-RECEPTOR, REPEAT 11===
==See Also==
 
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
 
== References ==
<!--  
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_12499540}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 12499540 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_12499540}}
 
==About this Structure==
1E6F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E6F OCA].
 
==Reference==
Locating the anomalous scatterer substructures in halide and sulfur phasing., Uson I, Schmidt B, von Bulow R, Grimme S, von Figura K, Dauter M, Rajashankar KR, Dauter Z, Sheldrick GM, Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):57-66. Epub 2002, Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12499540 12499540]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Buelow, R Von.]]
[[Category: Dauter M]]
[[Category: Dauter, M.]]
[[Category: Dauter Z]]
[[Category: Dauter, Z.]]
[[Category: Grimme S]]
[[Category: Figura, K Von.]]
[[Category: Rajashankar KR]]
[[Category: Grimme, S.]]
[[Category: Schmidt B]]
[[Category: Rajashankar, K R.]]
[[Category: Uson I]]
[[Category: Schmidt, B.]]
[[Category: Von Buelow R]]
[[Category: Uson, I.]]
[[Category: Von Figura K]]
[[Category: Glycoprotein]]
[[Category: Igf-ii receptor]]
[[Category: Mir-receptor]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:13:43 2008''

Latest revision as of 09:59, 20 March 2024

Human MIR-receptor, repeat 11

1e6f, resolution 1.75Å

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