1ehk: Difference between revisions

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{{Seed}}
[[Image:1ehk.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE ABERRANT BA3-CYTOCHROME-C OXIDASE FROM THERMUS THERMOPHILUS==
The line below this paragraph, containing "STRUCTURE_1ehk", creates the "Structure Box" on the page.
<StructureSection load='1ehk' size='340' side='right'caption='[[1ehk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ehk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EHK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=CUA:DINUCLEAR+COPPER+ION'>CUA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
{{STRUCTURE_1ehk|  PDB=1ehk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ehk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ehk OCA], [https://pdbe.org/1ehk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ehk RCSB], [https://www.ebi.ac.uk/pdbsum/1ehk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ehk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COX1_THET8 COX1_THET8]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/1ehk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ehk ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cytochrome c oxidase is a respiratory enzyme catalysing the energy-conserving reduction of molecular oxygen to water. The crystal structure of the ba(3)-cytochrome c oxidase from Thermus thermophilus has been determined to 2.4 A resolution using multiple anomalous dispersion (MAD) phasing and led to the discovery of a novel subunit IIa. A structure-based sequence alignment of this phylogenetically very distant oxidase with the other structurally known cytochrome oxidases leads to the identification of sequence motifs and residues that seem to be indispensable for the function of the haem copper oxidases, e.g. a new electron transfer pathway leading directly from Cu(A) to Cu(B). Specific features of the ba(3)-oxidase include an extended oxygen input channel, which leads directly to the active site, the presence of only one oxygen atom (O(2-), OH(-) or H(2)O) as bridging ligand at the active site and the mainly hydrophobic character of the interactions that stabilize the electron transfer complex between this oxidase and its substrate cytochrome c. New aspects of the proton pumping mechanism could be identified.


===CRYSTAL STRUCTURE OF THE ABERRANT BA3-CYTOCHROME-C OXIDASE FROM THERMUS THERMOPHILUS===
Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus.,Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME EMBO J. 2000 Apr 17;19(8):1766-76. PMID:10775261<ref>PMID:10775261</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ehk" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_10775261}}, adds the Publication Abstract to the page
*[[Cytochrome c oxidase 3D structures|Cytochrome c oxidase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 10775261 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_10775261}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1EHK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHK OCA].
[[Category: Thermus thermophilus HB8]]
 
[[Category: Bartunik HD]]
==Reference==
[[Category: Bourenkov GP]]
Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus., Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME, EMBO J. 2000 Apr 17;19(8):1766-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10775261 10775261]
[[Category: Buse G]]
[[Category: Cytochrome-c oxidase]]
[[Category: Huber R]]
[[Category: Protein complex]]
[[Category: Soulimane T]]
[[Category: Thermus thermophilus]]
[[Category: Than ME]]
[[Category: Bartunik, H D.]]
[[Category: Bourenkov, G P.]]
[[Category: Buse, G.]]
[[Category: Huber, R.]]
[[Category: Soulimane, T.]]
[[Category: Than, M E.]]
[[Category: Cytochrome-c oxidase]]
[[Category: Membrane protein]]
[[Category: Thermus thermophilus]]
 
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Retrieved from "https://proteopedia.org/1ehk"