1em1: Difference between revisions

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{{Seed}}
[[Image:1em1.png|left|200px]]


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==X-RAY CRYSTAL STRUCTURE FOR HUMAN MANGANESE SUPEROXIDE DISMUTASE, Q143A==
The line below this paragraph, containing "STRUCTURE_1em1", creates the "Structure Box" on the page.
<StructureSection load='1em1' size='340' side='right'caption='[[1em1]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1em1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EM1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1em1| PDB=1em1 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1em1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1em1 OCA], [https://pdbe.org/1em1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1em1 RCSB], [https://www.ebi.ac.uk/pdbsum/1em1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1em1 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN] Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:[https://omim.org/entry/612634 612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
== Function ==
[https://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.<ref>PMID:10334867</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/1em1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1em1 ConSurf].
<div style="clear:both"></div>


===X-RAY CRYSTAL STRUCTURE FOR HUMAN MANGANESE SUPEROXIDE DISMUTASE, Q143A===
==See Also==
 
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
 
== References ==
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<references/>
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__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 10852710 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_10852710}}
 
==About this Structure==
1EM1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EM1 OCA].
 
==Reference==
Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis., Leveque VJ, Stroupe ME, Lepock JR, Cabelli DE, Tainer JA, Nick HS, Silverman DN, Biochemistry. 2000 Jun 20;39(24):7131-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10852710 10852710]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Superoxide dismutase]]
[[Category: Cabelli DE]]
[[Category: Cabelli, D E.]]
[[Category: Lepock JR]]
[[Category: Lepock, J R.]]
[[Category: Leveque V]]
[[Category: Leveque, V.]]
[[Category: Nick HS]]
[[Category: Nick, H S.]]
[[Category: Silverman DN]]
[[Category: Silverman, D N.]]
[[Category: Stroupe ME]]
[[Category: Stroupe, M E.]]
[[Category: Tainer JA]]
[[Category: Tainer, J A.]]
[[Category: Alpha-beta protein]]
[[Category: Metalloenzyme]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:58:00 2008''
Retrieved from "https://proteopedia.org/1em1"