1emq: Difference between revisions

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{{Seed}}
[[Image:1emq.png|left|200px]]


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==NMR OBSERVATION OF T-TETRADS IN A PARALLEL STRANDED DNA QUADRUPLEX FORMED BY SACCHAROMYCES CEREVISIAE TELOMERE REPEATS==
The line below this paragraph, containing "STRUCTURE_1emq", creates the "Structure Box" on the page.
<StructureSection load='1emq' size='340' side='right'caption='[[1emq]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1emq]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EMQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1emq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1emq OCA], [https://pdbe.org/1emq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1emq RCSB], [https://www.ebi.ac.uk/pdbsum/1emq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1emq ProSAT]</span></td></tr>
{{STRUCTURE_1emq|  PDB=1emq  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report here the NMR structure of the DNA sequence d-TGGTGGC containing two repeats of Saccharomyces cerevisiae telomere DNA which is unique in that it has a single thymine in the repeat sequence and the number of Gs can vary from one to three. The structure is a novel quadruplex incor-porating T-tetrads formed by symmetrical pairing of four Ts via O4-H3 H-bonds in a plane. This is in contrast to the previous results on other telomeric sequences which contained more than one T in the repeat sequences and they were seen mostly in the flexible regions of the structures. We observed that the T4-tetrad was nicely accommodated in the center of the G-quadruplex, but it caused a small underwinding of the right handed helix. The T tetrad stacked well on the adjacent G3-tetrad, but poorly on the G5 tetrad. Likewise, T1 also formed a stable T-tetrad at the 5' end of the quadruplex. To our knowledge, this is the first report of T-tetrad formation in DNA structures. These observations are of significance from the points of view of both structural diversity and specific recognitions.


===NMR OBSERVATION OF T-TETRADS IN A PARALLEL STRANDED DNA QUADRUPLEX FORMED BY SACCHAROMYCES CEREVISIAE TELOMERE REPEATS===
NMR observation of T-tetrads in a parallel stranded DNA quadruplex formed by Saccharomyces cerevisiae telomere repeats.,Patel PK, Hosur RV Nucleic Acids Res. 1999 Jun 15;27(12):2457-64. PMID:10352174<ref>PMID:10352174</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1emq" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 10352174 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_10352174}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMQ OCA].
[[Category: Hosur RV]]
 
[[Category: Patel PK]]
==Reference==
NMR observation of T-tetrads in a parallel stranded DNA quadruplex formed by Saccharomyces cerevisiae telomere repeats., Patel PK, Hosur RV, Nucleic Acids Res. 1999 Jun 15;27(12):2457-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10352174 10352174]
[[Category: Hosur, R V.]]
[[Category: Patel, P K.]]
[[Category: G-quadruplex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: T-tetrad]]
[[Category: Telomere]]
[[Category: Yeast]]
 
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