1es9: Difference between revisions

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{{Seed}}
[[Image:1es9.png|left|200px]]


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==X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH)==
The line below this paragraph, containing "STRUCTURE_1es9", creates the "Structure Box" on the page.
<StructureSection load='1es9' size='340' side='right'caption='[[1es9]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1es9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ES9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1es9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1es9 OCA], [https://pdbe.org/1es9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1es9 RCSB], [https://www.ebi.ac.uk/pdbsum/1es9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1es9 ProSAT]</span></td></tr>
{{STRUCTURE_1es9|  PDB=1es9  |  SCENE=  }}
</table>
 
== Function ==
===X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH)===
[https://www.uniprot.org/uniprot/PA1B3_BOVIN PA1B3_BOVIN] Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11239086 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/1es9_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_11239086}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1es9 ConSurf].
1ES9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES9 OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib)., McMullen TW, Li J, Sheffield PJ, Aoki J, Martin TW, Arai H, Inoue K, Derewenda ZS, Protein Eng. 2000 Dec;13(12):865-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11239086 11239086]
[[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Aoki, J.]]
[[Category: Aoki J]]
[[Category: Arai, H.]]
[[Category: Arai H]]
[[Category: Derewenda, Z S.]]
[[Category: Derewenda ZS]]
[[Category: Inoue, K.]]
[[Category: Inoue K]]
[[Category: Li, J.]]
[[Category: Li J]]
[[Category: Martin, T W.]]
[[Category: Martin TW]]
[[Category: McMullen, T W.P.]]
[[Category: McMullen TWP]]
[[Category: Sheffield, P J.]]
[[Category: Sheffield PJ]]
[[Category: Alpha/beta hydrolase fold]]
 
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Retrieved from "https://proteopedia.org/1es9"