1fxv: Difference between revisions

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{{Seed}}
[[Image:1fxv.png|left|200px]]


<!--
==PENICILLIN ACYLASE MUTANT IMPAIRED IN CATALYSIS WITH PENICILLIN G IN THE ACTIVE SITE==
The line below this paragraph, containing "STRUCTURE_1fxv", creates the "Structure Box" on the page.
<StructureSection load='1fxv' size='340' side='right'caption='[[1fxv]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1fxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FXV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PNN:PENICILLIN+G'>PNN</scene></td></tr>
{{STRUCTURE_1fxv|  PDB=1fxv |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fxv OCA], [https://pdbe.org/1fxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fxv RCSB], [https://www.ebi.ac.uk/pdbsum/1fxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fxv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAC_ECOLX PAC_ECOLX]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/1fxv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fxv ConSurf].
<div style="clear:both"></div>


===PENICILLIN ACYLASE MUTANT IMPAIRED IN CATALYSIS WITH PENICILLIN G IN THE ACTIVE SITE===
==See Also==
 
*[[Penicillin acylase|Penicillin acylase]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_11239085}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11239085 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11239085}}
 
==About this Structure==
1FXV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FXV OCA].
 
==Reference==
Characterization of the beta-lactam binding site of penicillin acylase of Escherichia coli by structural and site-directed mutagenesis studies., Alkema WB, Hensgens CM, Kroezinga EH, de Vries E, Floris R, van der Laan JM, Dijkstra BW, Janssen DB, Protein Eng. 2000 Dec;13(12):857-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11239085 11239085]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Penicillin amidase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Alkema WB]]
[[Category: Alkema, W B]]
[[Category: Dijkstra BW]]
[[Category: Dijkstra, B W.]]
[[Category: Floris R]]
[[Category: Floris, R.]]
[[Category: Hensgens CM]]
[[Category: Hensgens, C M]]
[[Category: Janssen DB]]
[[Category: Janssen, D B.]]
[[Category: Kroezinga EH]]
[[Category: Kroezinga, E H.]]
[[Category: De Vries E]]
[[Category: Laan, J M.van der.]]
[[Category: Van der Laan JM]]
[[Category: Vries, E de.]]
[[Category: Ntn-hydrolase fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:06:17 2008''
Retrieved from "https://proteopedia.org/1fxv"