1git: Difference between revisions

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{{Seed}}
[[Image:1git.png|left|200px]]


<!--
==STRUCTURE OF GTP-BINDING PROTEIN==
The line below this paragraph, containing "STRUCTURE_1git", creates the "Structure Box" on the page.
<StructureSection load='1git' size='340' side='right'caption='[[1git]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1git]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GIT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_1git| PDB=1git |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1git FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1git OCA], [https://pdbe.org/1git PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1git RCSB], [https://www.ebi.ac.uk/pdbsum/1git PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1git ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/1git_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1git ConSurf].
<div style="clear:both"></div>


===STRUCTURE OF GTP-BINDING PROTEIN===
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_8939752}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 8939752 is the PubMed ID number.
</StructureSection>
-->
[[Category: Large Structures]]
{{ABSTRACT_PUBMED_8939752}}
 
==About this Structure==
1GIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIT OCA].
 
==Reference==
Structure of the GDP-Pi complex of Gly203--&gt;Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis., Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR, Structure. 1996 Nov 15;4(11):1277-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8939752 8939752]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Berghuis AM]]
[[Category: Berghuis, A M.]]
[[Category: Lee E]]
[[Category: Lee, E.]]
[[Category: Sprang SR]]
[[Category: Sprang, S R.]]
[[Category: Adenylate cyclase]]
[[Category: Gtp-ase]]
[[Category: Gtp-binding protein]]
[[Category: Multigene family]]
[[Category: Myristylation]]
[[Category: Transducer]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:21:46 2008''
Retrieved from "https://proteopedia.org/1git"