1gsf: Difference between revisions

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{{Seed}}
[[Image:1gsf.png|left|200px]]


<!--
==GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID==
The line below this paragraph, containing "STRUCTURE_1gsf", creates the "Structure Box" on the page.
<StructureSection load='1gsf' size='340' side='right'caption='[[1gsf]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1gsf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSF FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAA:ETHACRYNIC+ACID'>EAA</scene></td></tr>
{{STRUCTURE_1gsf|  PDB=1gsf |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsf OCA], [https://pdbe.org/1gsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsf RCSB], [https://www.ebi.ac.uk/pdbsum/1gsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GSTA1_HUMAN GSTA1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:20606271</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/1gsf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gsf ConSurf].
<div style="clear:both"></div>


===GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID===
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
 
== References ==
<!--  
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_8591048}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 8591048 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_8591048}}
 
==About this Structure==
1GSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSF OCA].
 
==Reference==
Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate., Cameron AD, Sinning I, L'Hermite G, Olin B, Board PG, Mannervik B, Jones TA, Structure. 1995 Jul 15;3(7):717-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8591048 8591048]
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cameron, A D.]]
[[Category: Cameron AD]]
[[Category: Hermite, G L.]]
[[Category: Jones TA]]
[[Category: Jones, T A.]]
[[Category: L'Hermite G]]
[[Category: Sinning, I.]]
[[Category: Sinning I]]
[[Category: A1-1]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:59:49 2008''
Retrieved from "https://proteopedia.org/1gsf"