1h30: Difference between revisions

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{{Seed}}
[[Image:1h30.png|left|200px]]


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==C-terminal LG domain pair of human Gas6==
The line below this paragraph, containing "STRUCTURE_1h30", creates the "Structure Box" on the page.
<StructureSection load='1h30' size='340' side='right'caption='[[1h30]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1h30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H30 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1h30|  PDB=1h30  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h30 OCA], [https://pdbe.org/1h30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h30 RCSB], [https://www.ebi.ac.uk/pdbsum/1h30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h30 ProSAT]</span></td></tr>
 
</table>
===C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6===
== Function ==
 
[https://www.uniprot.org/uniprot/GAS6_HUMAN GAS6_HUMAN] Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.<ref>PMID:12364394</ref> <ref>PMID:18840707</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_12218057}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h30_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_12218057}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1H30 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h30 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12218057 12218057]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cheburkin, Y.]]
[[Category: Cheburkin Y]]
[[Category: Gohring, W.]]
[[Category: Gohring W]]
[[Category: Hohenester, E.]]
[[Category: Hohenester E]]
[[Category: Knyazev, P G.]]
[[Category: Knyazev PG]]
[[Category: Sasaki, T.]]
[[Category: Sasaki T]]
[[Category: Timpl, R.]]
[[Category: Timpl R]]
[[Category: Tisi, D.]]
[[Category: Tisi D]]
[[Category: Ullrich, A.]]
[[Category: Ullrich A]]
[[Category: Axl/sky/mer ligand]]
[[Category: Calcium-binding]]
[[Category: Egf-like domain]]
[[Category: Laminin g-like domain]]
[[Category: Vitamin k-dependent protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 06:32:24 2008''
Retrieved from "https://proteopedia.org/1h30"