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New page: left|200px<br /><applet load="1g0w" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g0w, resolution 2.30Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1g0w.jpg|left|200px]]<br /><applet load="1g0w" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1g0w, resolution 2.30&Aring;" />
'''CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE'''<br />


==Overview==
==CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE==
Creatine kinase (CK) catalyses the reversible transfer of the phosphate, moiety from phosphocreatine (PCr) to ADP, generating creatine and ATP. The, crystal structure of a cytosolic brain-type creatine kinase is reported at, 2.3 A. The biological dimer sits on a crystallographic twofold axis. The, N-terminal residues of both subunits come very close to the, crystallographic twofold at the dimer interface. The electron density, observed is consistent with two alternative conformations for the, N-termini, as previously found for chicken brain-type creatine kinase.
<StructureSection load='1g0w' size='340' side='right'caption='[[1g0w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1g0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G0W FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g0w OCA], [https://pdbe.org/1g0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g0w RCSB], [https://www.ebi.ac.uk/pdbsum/1g0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g0w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCRM_BOVIN KCRM_BOVIN] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/1g0w_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g0w ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1G0W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Creatine_kinase Creatine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.2 2.7.3.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1G0W OCA].
*[[Creatine kinase 3D structures|Creatine kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
The three-dimensional structure of cytosolic bovine retinal creatine kinase., Tisi D, Bax B, Loew A, Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):187-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11173463 11173463]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Creatine kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Bax B]]
[[Category: Bax, B.]]
[[Category: Loew A]]
[[Category: Loew, A.]]
[[Category: Tisi D]]
[[Category: Tisi, D.]]
[[Category: SO4]]
[[Category: brain-type creatine kinase]]
[[Category: guanidino kinase cellular energy metabolism]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:36:26 2007''

Latest revision as of 07:21, 7 February 2024

CRYSTAL STRUCTURE OF BOVINE RETINAL CREATINE KINASE

1g0w, resolution 2.30Å

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