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New page: left|200px<br /> <applet load="1ofo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ofo, resolution 1.86Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:1ofo.gif|left|200px]]<br />
<applet load="1ofo" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ofo, resolution 1.86&Aring;" />
'''CRYSTAL STRUCTURE OF THE TYROSINE REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH 2-PHOSPHOGLYCOLATE'''<br />


==About this Structure==
==Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae in Complex with 2-Phosphoglycolate==
1OFO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with PGA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.15 4.1.2.15]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OFO OCA]].
<StructureSection load='1ofo' size='340' side='right'caption='[[1ofo]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ofo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OFO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ofo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ofo OCA], [https://pdbe.org/1ofo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ofo RCSB], [https://www.ebi.ac.uk/pdbsum/1ofo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ofo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AROG_YEAST AROG_YEAST] Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/1ofo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ofo ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Braus G]]
[[Category: Braus, G.]]
[[Category: Heinrich G]]
[[Category: Heinrich, G.]]
[[Category: Koenig V]]
[[Category: Koenig, V.]]
[[Category: Pfeil A]]
[[Category: Pfeil, A.]]
[[Category: Schneider TR]]
[[Category: Schneider, T.R.]]
[[Category: PGA]]
[[Category: aldolase]]
[[Category: aromatic amino-acid biosynthesis synthase]]
[[Category: beta-alpha-barrel]]
[[Category: lyase]]
[[Category: manganese]]
[[Category: synthetase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:53:38 2007''

Latest revision as of 06:32, 1 May 2024

Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae in Complex with 2-Phosphoglycolate

1ofo, resolution 1.86Å

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