1hrl: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:1hrl.png|left|200px]]


<!--
==STRUCTURE OF A PARALYTIC PEPTIDE FROM AN INSECT, MANDUCA SEXTA==
The line below this paragraph, containing "STRUCTURE_1hrl", creates the "Structure Box" on the page.
<StructureSection load='1hrl' size='340' side='right'caption='[[1hrl]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hrl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HRL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hrl OCA], [https://pdbe.org/1hrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hrl RCSB], [https://www.ebi.ac.uk/pdbsum/1hrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hrl ProSAT]</span></td></tr>
-->
</table>
{{STRUCTURE_1hrl|  PDB=1hrl  |  SCENE=  }}
== Function ==
[https://www.uniprot.org/uniprot/PAP1_MANSE PAP1_MANSE] Causes rapid, rigid paralysis when injected into Lepidopteran larvae. The physiological role may be to reduce hemolymph loss following injury and promote wound healing.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Paralytic peptide 1 (PP1) from a moth, Manduca sexta, is a 23-residue peptide (Glu-Asn-Phe-Ala-Gly-Gly-Cys-Ala-Thr-Gly-Tyr-Leu-Arg-Thr-Ala-Asp-Gly-Arg -Cys-Lys-Pro-Thr-Phe) that was first found to have paralytic activity when injected into M. sexta larvae. Recent studies demonstrated that PP1 also stimulated the spreading and aggregation of a blood cell type called plasmatocytes and inhibited bleeding from wounds. We determined the solution structure of PP1 by two-dimensional 1H NMR spectroscopy to begin to understand structural-functional relationships of this peptide. PP1 has an ordered structure, which is composed of a short antiparallel beta-sheet at residues Tyr11-Thr14 and Arg18-Pro21, three beta turns at residues Phe3-Gly6, Ala8-Tyr11 and Thr14-Gly17, and a half turn at the carboxyl-terminus (residues Lys20-Phe23). The well-defined secondary and tertiary structure was stabilized by hydrogen bonding and side-chain hydrophobic interactions. In comparison with two related insect peptides, whose structures have been solved recently, the amino-terminal region of PP1 is substantially more ordered. The short antiparallel beta-sheet of PP1 has a folding pattern similar to the carboxyl-terminal subdomain of epidermal growth factor (EGF). Therefore, PP1 may interact with EGF receptor-like molecules to trigger its different biological activities.


===STRUCTURE OF A PARALYTIC PEPTIDE FROM AN INSECT, MANDUCA SEXTA===
Structure of a paralytic peptide from an insect, Manduca sexta.,Yu XQ, Prakash O, Kanost MR J Pept Res. 1999 Sep;54(3):256-61. PMID:10517164<ref>PMID:10517164</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_10517164}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1hrl" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 10517164 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_10517164}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1HRL is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRL OCA].
[[Category: Manduca sexta]]
 
[[Category: Kanost MR]]
==Reference==
[[Category: Prakash O]]
Structure of a paralytic peptide from an insect, Manduca sexta., Yu XQ, Prakash O, Kanost MR, J Pept Res. 1999 Sep;54(3):256-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10517164 10517164]
[[Category: Yu X-Q]]
[[Category: Single protein]]
[[Category: Kanost, M R.]]
[[Category: Prakash, O.]]
[[Category: Yu, X Q.]]
[[Category: Enf family]]
[[Category: Paralytic peptide]]
[[Category: Plasmatocyte spreading peptide]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:35:29 2008''

Latest revision as of 07:15, 10 May 2023

STRUCTURE OF A PARALYTIC PEPTIDE FROM AN INSECT, MANDUCA SEXTA

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1hrl&oldid=3764622"