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{{Seed}}
[[Image:1i47.png|left|200px]]


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==MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA==
The line below this paragraph, containing "STRUCTURE_1i47", creates the "Structure Box" on the page.
<StructureSection load='1i47' size='340' side='right'caption='[[1i47]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1i47]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I47 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C45:N4-METHOXY-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C45</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1i47|  PDB=1i47  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i47 OCA], [https://pdbe.org/1i47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i47 RCSB], [https://www.ebi.ac.uk/pdbsum/1i47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i47 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
To investigate the mutation mechanism of purine transition in DNA damaged with methoxyamine, a DNA dodecamer with the sequence d(CGCGAATTmo(4)CGCG), where mo(4)C is 2'-deoxy-N(4)-methoxycytidine, has been synthesized and its crystal structure determined. Two dodecamers form a B-form duplex. Electron density maps clearly show that one of the two mo(4)C residues forms a pair with a guanine residue of the opposite strand, the geometry being the canonical Watson-Crick type, and that the other mo(4)C residue forms a wobble pair with the opposite guanine residue. These two pairings are ascribed to the tautomerization of the methoxylated cytosine moieties between the amino and imino forms.


===MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA===
Crystallographic studies on damaged DNAs: III. N(4)-methoxycytosine can form both Watson-Crick type and wobbled base pairs in a B-form duplex.,Hossain MT, Chatake T, Hikima T, Tsunoda M, Sunami T, Ueno Y, Matsuda A, Takenaka A J Biochem. 2001 Jul;130(1):9-12. PMID:11432773<ref>PMID:11432773</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_11432773}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1i47" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 11432773 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_11432773}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I47 OCA].
[[Category: Chatake T]]
 
[[Category: Hikima T]]
==Reference==
[[Category: Hossain MT]]
Crystallographic studies on damaged DNAs: III. N(4)-methoxycytosine can form both Watson-Crick type and wobbled base pairs in a B-form duplex., Hossain MT, Chatake T, Hikima T, Tsunoda M, Sunami T, Ueno Y, Matsuda A, Takenaka A, J Biochem. 2001 Jul;130(1):9-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11432773 11432773]
[[Category: Matsuda A]]
[[Category: Chatake, T.]]
[[Category: Sunami T]]
[[Category: Hikima, T.]]
[[Category: Takenaka A]]
[[Category: Hossain, M T.]]
[[Category: Tsunoda M]]
[[Category: Matsuda, A.]]
[[Category: Ueno Y]]
[[Category: Sunami, T.]]
[[Category: Takenaka, A.]]
[[Category: Tsunoda, M.]]
[[Category: Ueno, Y.]]
[[Category: B-dna]]
[[Category: Damaged dna]]
[[Category: Deoxyribonucleic acid]]
[[Category: Double helix]]
[[Category: N4-methoxycytosine]]
 
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Retrieved from "https://proteopedia.org/1i47"