1jbk: Difference between revisions

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{{Seed}}
[[Image:1jbk.png|left|200px]]


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==Crystal Structure of the First Nucelotide Binding Domain of ClpB==
The line below this paragraph, containing "STRUCTURE_1jbk", creates the "Structure Box" on the page.
<StructureSection load='1jbk' size='340' side='right'caption='[[1jbk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1jbk| PDB=1jbk |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbk OCA], [https://pdbe.org/1jbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbk RCSB], [https://www.ebi.ac.uk/pdbsum/1jbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLPB_ECOLI CLPB_ECOLI] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.<ref>PMID:10982797</ref> <ref>PMID:12624113</ref> <ref>PMID:14640692</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jbk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jbk ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the First Nucelotide Binding Domain of ClpB===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
*[[3D structures of ClpB|3D structures of ClpB]]
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== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_12054807}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 12054807 is the PubMed ID number.
__TOC__
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</StructureSection>
{{ABSTRACT_PUBMED_12054807}}
 
==About this Structure==
1JBK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBK OCA].
 
==Reference==
Crystal structure of E. coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1) and mechanistic studies on ClpB ATPase activity., Li J, Sha B, J Mol Biol. 2002 May 10;318(4):1127-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12054807 12054807]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bingdong, S.]]
[[Category: Bingdong S]]
[[Category: Jingzhi, L.]]
[[Category: Jingzhi L]]
[[Category: Beta barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 19:58:31 2008''
Retrieved from "https://proteopedia.org/1jbk"