1jdm: Difference between revisions

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{{Seed}}
[[Image:1jdm.png|left|200px]]


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==NMR Structure of Sarcolipin==
The line below this paragraph, containing "STRUCTURE_1jdm", creates the "Structure Box" on the page.
<StructureSection load='1jdm' size='340' side='right'caption='[[1jdm]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jdm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JDM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jdm OCA], [https://pdbe.org/1jdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jdm RCSB], [https://www.ebi.ac.uk/pdbsum/1jdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jdm ProSAT]</span></td></tr>
{{STRUCTURE_1jdm|  PDB=1jdm  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SARCO_HUMAN SARCO_HUMAN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Sarcolipin (SLN) is a 31 amino acid integral membrane protein that regulates Ca-ATPase activity in skeletal muscle. Here, we report the three-dimensional structure and topology of synthetic SLN in lipid environments, as determined by solution and solid-state NMR spectroscopy. 2D solution NMR experiments were performed on SLN solubilized in sodium dodecyl sulfate (SDS) micelles. We found that SLN adopts a highly defined alpha-helical conformation from F9 through R27, with a backbone RMSD of 0.65 A and a side chain RMSD of 1.66 A. The N-terminus (M1 through L8) and the C-terminus (S28 through Y31) are mostly unstructured. The orientation of the SLN was determined using one-dimensional (15)N NMR solid-state spectroscopy. The protein was incorporated into phospholipid bilayers prepared from a mixture of 1,2-dioleoyl-sn-glycero-3-phosphocholine and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine. The (15)N chemical shift solid-state spectra from selectively labeled SLN samples indicate that SLN orients perpendicularly to the plane of the membrane bilayers. These results support the proposed mechanism of Ca-ATPase regulation of SLN via protein-protein intramembranous interactions between the highly conserved transmembrane domains of the Ca-ATPase and the conserved transmembrane domain of SLN.


===NMR Structure of Sarcolipin===
Structure and orientation of sarcolipin in lipid environments.,Mascioni A, Karim C, Barany G, Thomas DD, Veglia G Biochemistry. 2002 Jan 15;41(2):475-82. PMID:11781085<ref>PMID:11781085</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_11781085}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1jdm" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 11781085 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_11781085}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
1JDM is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JDM OCA].
[[Category: Large Structures]]
 
[[Category: Mascioni A]]
==Reference==
[[Category: Veglia G]]
Structure and orientation of sarcolipin in lipid environments., Mascioni A, Karim C, Barany G, Thomas DD, Veglia G, Biochemistry. 2002 Jan 15;41(2):475-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11781085 11781085]
[[Category: Single protein]]
[[Category: Mascioni, A.]]
[[Category: Veglia, G.]]
[[Category: Helix]]
 
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Latest revision as of 18:43, 29 November 2023

NMR Structure of Sarcolipin

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