1jk2: Difference between revisions

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{{Seed}}
[[Image:1jk2.png|left|200px]]


<!--
==Zif268 D20A mutant bound to the GCT DNA site==
The line below this paragraph, containing "STRUCTURE_1jk2", creates the "Structure Box" on the page.
<StructureSection load='1jk2' size='340' side='right'caption='[[1jk2]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jk2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JK2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1jk2|  PDB=1jk2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jk2 OCA], [https://pdbe.org/1jk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jk2 RCSB], [https://www.ebi.ac.uk/pdbsum/1jk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jk2 ProSAT]</span></td></tr>
 
</table>
===Zif268 D20A mutant bound to the GCT DNA site===
== Function ==
 
[https://www.uniprot.org/uniprot/EGR1_MOUSE EGR1_MOUSE] Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_11800559}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 11800559 is the PubMed ID number.
  <jmolCheckbox>
-->
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/1jk2_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_11800559}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1JK2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JK2 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jk2 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Rearrangement of side-chains in a Zif268 mutant highlights the complexities of zinc finger-DNA recognition., Miller JC, Pabo CO, J Mol Biol. 2001 Oct 19;313(2):309-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11800559 11800559]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Miller JC]]
[[Category: Miller, J C.]]
[[Category: Pabo CO]]
[[Category: Pabo, C O.]]
[[Category: Double stranded dna]]
[[Category: Protein-dna complex]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 20:21:56 2008''
Retrieved from "https://proteopedia.org/1jk2"