1jkw: Difference between revisions

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{{Seed}}
[[Image:1jkw.png|left|200px]]


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==STRUCTURE OF CYCLIN MCS2==
The line below this paragraph, containing "STRUCTURE_1jkw", creates the "Structure Box" on the page.
<StructureSection load='1jkw' size='340' side='right'caption='[[1jkw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jkw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JKW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkw OCA], [https://pdbe.org/1jkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jkw RCSB], [https://www.ebi.ac.uk/pdbsum/1jkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jkw ProSAT]</span></td></tr>
{{STRUCTURE_1jkw|  PDB=1jkw  |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCNH_HUMAN CCNH_HUMAN] Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.<ref>PMID:7533895</ref> <ref>PMID:10024882</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/1jkw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jkw ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of human cyclin H has been solved at 2.6 A resolution by the MIR method and refined to an R-factor of 23.1%. The core of the molecule consists of two helical repeats adopting the canonical cyclin fold already observed in the structures of cyclin A [Brown et al. (1995) Structure 3, 1235-1247; Jeffrey et al. (1995) Nature 376, 313-320; Russo et al. (1996) Nature 382, 325-331] and TFIIB [Nikoilov et al. (1995) Nature 377, 119-128]. The N-terminal and C-terminal residues form a new domain built on two long helices interacting essentially with the first repeat of the molecule.


===STRUCTURE OF CYCLIN MCS2===
The crystal structure of human cyclin H.,Andersen G, Poterszman A, Egly JM, Moras D, Thierry JC FEBS Lett. 1996 Nov 11;397(1):65-9. PMID:8941715<ref>PMID:8941715</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1jkw" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_8941715}}, adds the Publication Abstract to the page
*[[Cyclin 3D structures|Cyclin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 8941715 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_8941715}}
__TOC__
 
</StructureSection>
==About this Structure==
1JKW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKW OCA].
 
==Reference==
The crystal structure of human cyclin H., Andersen G, Poterszman A, Egly JM, Moras D, Thierry JC, FEBS Lett. 1996 Nov 11;397(1):65-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8941715 8941715]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Andersen, G.]]
[[Category: Andersen G]]
[[Category: Moras, D.]]
[[Category: Moras D]]
[[Category: Poterszman, A.]]
[[Category: Poterszman A]]
[[Category: Thierry, J C.]]
[[Category: Thierry JC]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cyclin]]
[[Category: Nuclear protein]]
 
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Retrieved from "https://proteopedia.org/1jkw"