1jt6: Difference between revisions

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{{Seed}}
[[Image:1jt6.png|left|200px]]


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==Crystal structure of the multidrug binding protein QacR bound to dequalinium==
The line below this paragraph, containing "STRUCTURE_1jt6", creates the "Structure Box" on the page.
<StructureSection load='1jt6' size='340' side='right'caption='[[1jt6]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jt6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JT6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEQ:DEQUALINIUM'>DEQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1jt6|  PDB=1jt6  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jt6 OCA], [https://pdbe.org/1jt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jt6 RCSB], [https://www.ebi.ac.uk/pdbsum/1jt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jt6 ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the multidrug binding protein QacR bound to dequalinium===
== Function ==
 
[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jt6_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_11739955}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1JT6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JT6 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jt6 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11739955 11739955]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Brennan, R G.]]
[[Category: Brennan RG]]
[[Category: Brown, M H.]]
[[Category: Brown MH]]
[[Category: Grkovic, S.]]
[[Category: Grkovic S]]
[[Category: Miller, M C.]]
[[Category: Miller MC]]
[[Category: Schumacher, M A.]]
[[Category: Schumacher MA]]
[[Category: Skurray, R A.]]
[[Category: Skurray RA]]
[[Category: Mulitdrug resistance]]
[[Category: Mutlidrug binding recognition]]
[[Category: Qacr]]
[[Category: S. aureus]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 20:45:57 2008''
Retrieved from "https://proteopedia.org/1jt6"