1hio: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: left|200px<br /><applet load="1hio" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hio, resolution 3.10Å" /> '''HISTONE OCTAMER (CHI...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(18 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1hio.gif|left|200px]]<br /><applet load="1hio" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1hio, resolution 3.10&Aring;" />
'''HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY'''<br />


==Overview==
==HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY==
The structure of the octameric histone core of the nucleosome has been, determined by x-ray crystallography to a resolution of 3.1 A. The histone, octamer is a tripartite assembly in which a centrally located (H3-H4)2, tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface;, depending on the perspective, the structure appears as a wedge or as a, flat disk. The disk represents the planar projection of a left-handed, proteinaceous superhelix with approximately 28 A pitch. The diameter of, the particle is 65 A and the length is 60 A at its maximum and, approximately 10 A at its minimum extension; these dimensions are in, agreement with those reported earlier by Klug et al. [Klug, A., Rhodes, D., Smith, J., Finch, J. T. &amp; Thomas, J. O. (1980) Nature (London) 287, 509-516]. The folded histone chains are elongated rather than globular and, are assembled in a characteristic "handshake" motif. The individual, polypeptides share a common central structural element of the, helix-loop-helix type, which we name the histone fold.
<StructureSection load='1hio' size='340' side='right'caption='[[1hio]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1hio]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HIO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hio OCA], [https://pdbe.org/1hio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hio RCSB], [https://www.ebi.ac.uk/pdbsum/1hio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hio ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H2A4_CHICK H2A4_CHICK] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/1hio_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hio ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1HIO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HIO OCA].
*[[Histone 3D structures|Histone 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix., Arents G, Burlingame RW, Wang BC, Love WE, Moudrianakis EN, Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10148-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1946434 1946434]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Arents, G.]]
[[Category: Arents G]]
[[Category: Moudrianakis, E.N.]]
[[Category: Moudrianakis EN]]
[[Category: chromosomal protein]]
[[Category: histone]]
[[Category: nucleosome core]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:36:03 2007''
Retrieved from "https://proteopedia.org/1hio"