1k25: Difference between revisions

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{{Seed}}
[[Image:1k25.png|left|200px]]


<!--
==PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate==
The line below this paragraph, containing "STRUCTURE_1k25", creates the "Structure Box" on the page.
<StructureSection load='1k25' size='340' side='right'caption='[[1k25]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1k25]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K25 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k25 OCA], [https://pdbe.org/1k25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k25 RCSB], [https://www.ebi.ac.uk/pdbsum/1k25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k25 ProSAT]</span></td></tr>
{{STRUCTURE_1k25|  PDB=1k25 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/O34006_STREE O34006_STREE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/1k25_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k25 ConSurf].
<div style="clear:both"></div>


===PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate===
==See Also==
 
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
 
__TOC__
<!--  
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_11553637}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 11553637 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11553637}}
 
==About this Structure==
1K25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K25 OCA].
 
==Reference==
Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations., Dessen A, Mouz N, Gordon E, Hopkins J, Dideberg O, J Biol Chem. 2001 Nov 30;276(48):45106-12. Epub 2001 Sep 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11553637 11553637]
[[Category: Single protein]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
[[Category: Dessen, A.]]
[[Category: Dessen A]]
[[Category: Dideberg, O.]]
[[Category: Dideberg O]]
[[Category: Hopkins, J.]]
[[Category: Hopkins J]]
[[Category: Mouz, N.]]
[[Category: Mouz N]]
[[Category: Antibiotic resistance]]
[[Category: Clinical mutant]]
[[Category: Low-affinity penicillin-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 21:24:43 2008''
Retrieved from "https://proteopedia.org/1k25"