1l2q: Difference between revisions

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{{Seed}}
[[Image:1l2q.png|left|200px]]


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==Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)==
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<StructureSection load='1l2q' size='340' side='right'caption='[[1l2q]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1l2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=XPL:N~6~-[(3R,5R)-5-AMINO-3-METHYL-D-PROLYL]-L-LYSINE'>XPL</scene></td></tr>
{{STRUCTURE_1l2q|  PDB=1l2q  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2q OCA], [https://pdbe.org/1l2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2q RCSB], [https://www.ebi.ac.uk/pdbsum/1l2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2q ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTMB1_METBA MTMB1_METBA] Catalyzes the transfer of the methyl group from monomethylamine to the corrinoid cofactor of MtmC (MtmC1 or MtmC2).<ref>PMID:9642198</ref> <ref>PMID:9195968</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.


===Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)===
A new UAG-encoded residue in the structure of a methanogen methyltransferase.,Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK Science. 2002 May 24;296(5572):1462-6. PMID:12029132<ref>PMID:12029132</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1l2q" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_12029132}}, adds the Publication Abstract to the page
*[[Monomethylamine methyltransferase|Monomethylamine methyltransferase]]
(as it appears on PubMed at http://www.pubmed.gov), where 12029132 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_12029132}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1L2Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri Methanosarcina barkeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2Q OCA].
 
==Reference==
A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12029132 12029132]
[[Category: Methanosarcina barkeri]]
[[Category: Methanosarcina barkeri]]
[[Category: Single protein]]
[[Category: Chan MK]]
[[Category: Chan, M K.]]
[[Category: Ferguson TK]]
[[Category: Ferguson, T K.]]
[[Category: Gong W]]
[[Category: Gong, W.]]
[[Category: Hao B]]
[[Category: Hao, B.]]
[[Category: James CM]]
[[Category: James, C M.]]
[[Category: Krzycki JA]]
[[Category: Krzycki, J A.]]
[[Category: Tim barrel]]
 
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