1i2l: Difference between revisions
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New page: left|200px<br /><applet load="1i2l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i2l, resolution 2.3Å" /> '''DEOXYCHORISMATE LYASE... |
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== | ==DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR== | ||
<StructureSection load='1i2l' size='340' side='right'caption='[[1i2l]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1i2l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I2L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCS:D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE'>DCS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2l OCA], [https://pdbe.org/1i2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i2l RCSB], [https://www.ebi.ac.uk/pdbsum/1i2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PABC_ECOLI PABC_ECOLI] Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.<ref>PMID:1644759</ref> <ref>PMID:2251281</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2l_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i2l ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Eisenstein | [[Category: Eisenstein E]] | ||
[[Category: Fisher | [[Category: Fisher KE]] | ||
[[Category: Howard | [[Category: Howard AJ]] | ||
[[Category: Jensen | [[Category: Jensen PY]] | ||
[[Category: Ladner | [[Category: Ladner JE]] | ||
[[Category: Pachikara | [[Category: Pachikara AS]] | ||
[[Category: Parsons | [[Category: Parsons JF]] | ||
[[Category: Tordova | [[Category: Tordova M]] | ||
