2v6g: Difference between revisions

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{{Seed}}
[[Image:2v6g.png|left|200px]]


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==Structure of Progesterone 5beta-Reductase from Digitalis Lanata in complex with NADP==
The line below this paragraph, containing "STRUCTURE_2v6g", creates the "Structure Box" on the page.
<StructureSection load='2v6g' size='340' side='right'caption='[[2v6g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2v6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6G FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_2v6g|  PDB=2v6g  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6g OCA], [https://pdbe.org/2v6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6g RCSB], [https://www.ebi.ac.uk/pdbsum/2v6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6g ProSAT]</span></td></tr>
 
</table>
===STRUCTURE OF PROGESTERONE 5BETA-REDUCTASE FROM DIGITALIS LANATA IN COMPLEX WITH NADP===
== Function ==
 
[https://www.uniprot.org/uniprot/5BPOR_DIGLA 5BPOR_DIGLA] Involved in cardenolide biosynthesis. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 4-androstene-3,17-dione, cortisol and cortisone as substrates, but not pregnenolone, 21-OH-pregnenolone or isoprogesterone. NADPH could not be replaced by NADH.<ref>PMID:16386278</ref> <ref>PMID:18032383</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v6/2v6g_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_18032383}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2V6G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6G OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v6g ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
The Crystal Structure of Progesterone 5{beta}-Reductase from Digitalis lanata Defines a Novel Class of Short Chain Dehydrogenases/Reductases., Thorn A, Egerer-Sieber C, Jager CM, Herl V, Muller-Uri F, Kreis W, Muller YA, J Biol Chem. 2008 Jun 20;283(25):17260-17269. Epub 2007 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18032383 18032383]
<references/>
__TOC__
</StructureSection>
[[Category: Digitalis lanata]]
[[Category: Digitalis lanata]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Egerer-Sieber, C.]]
[[Category: Egerer-Sieber C]]
[[Category: Herl, V.]]
[[Category: Herl V]]
[[Category: Jaeger, C.]]
[[Category: Jaeger C]]
[[Category: Kreis, W.]]
[[Category: Kreis W]]
[[Category: Mueller-Uri, F.]]
[[Category: Mueller-Uri F]]
[[Category: Muller, Y A.]]
[[Category: Muller YA]]
[[Category: Thorn, A.]]
[[Category: Thorn A]]
[[Category: Cardenolide]]
[[Category: Cardiac glycoside]]
[[Category: Oxidoreductase]]
[[Category: Reductase]]
[[Category: Sdr]]
[[Category: Tyrosine-dependent oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 21:43:22 2008''
Retrieved from "https://proteopedia.org/2v6g"