1lry: Difference between revisions

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{{Seed}}
[[Image:1lry.png|left|200px]]


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==Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin==
The line below this paragraph, containing "STRUCTURE_1lry", creates the "Structure Box" on the page.
<StructureSection load='1lry' size='340' side='right'caption='[[1lry]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1lry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LRY FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1lry|  PDB=1lry  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lry OCA], [https://pdbe.org/1lry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lry RCSB], [https://www.ebi.ac.uk/pdbsum/1lry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lry ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin===
== Function ==
 
[https://www.uniprot.org/uniprot/DEF_PSEAE DEF_PSEAE] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_12126617}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 12126617 is the PubMed ID number.
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lry_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_12126617}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1LRY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRY OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lry ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents., Guilloteau JP, Mathieu M, Giglione C, Blanc V, Dupuy A, Chevrier M, Gil P, Famechon A, Meinnel T, Mikol V, J Mol Biol. 2002 Jul 26;320(5):951-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12126617 12126617]
</StructureSection>
[[Category: Peptide deformylase]]
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Blanc V]]
[[Category: Blanc, V.]]
[[Category: Chevrier M]]
[[Category: Chevrier, M.]]
[[Category: Dupuy A]]
[[Category: Dupuy, A.]]
[[Category: Famechon A]]
[[Category: Famechon, A.]]
[[Category: Giglione C]]
[[Category: Giglione, C.]]
[[Category: Gil P]]
[[Category: Gil, P.]]
[[Category: Guilloteau J-P]]
[[Category: Guilloteau, J P.]]
[[Category: Mathieu M]]
[[Category: Mathieu, M.]]
[[Category: Meinnel T]]
[[Category: Meinnel, T.]]
[[Category: Mikol V]]
[[Category: Mikol, V.]]
[[Category: Actinonin]]
[[Category: Inhibition]]
[[Category: Polypeptide deformylase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 21:55:58 2008''

Latest revision as of 07:35, 14 February 2024

Crystal Structure of P. aeruginosa Peptide Deformylase Complexed with Antibiotic Actinonin

1lry, resolution 2.60Å

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