1m1u: Difference between revisions

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{{Seed}}
[[Image:1m1u.png|left|200px]]


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==AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN==
The line below this paragraph, containing "STRUCTURE_1m1u", creates the "Structure Box" on the page.
<StructureSection load='1m1u' size='340' side='right'caption='[[1m1u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1U FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_1m1u| PDB=1m1u |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1u OCA], [https://pdbe.org/1m1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1u RCSB], [https://www.ebi.ac.uk/pdbsum/1m1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1u ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
== Function ==
[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1u ConSurf].
<div style="clear:both"></div>


===AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN===
==See Also==
 
*[[Integrin 3D structures|Integrin 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_11034990}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11034990 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11034990}}
 
==About this Structure==
1M1U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1U OCA].
 
==Reference==
An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain., Xiong JP, Li R, Essafi M, Stehle T, Arnaout MA, J Biol Chem. 2000 Dec 8;275(49):38762-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11034990 11034990]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arnaout, M A.]]
[[Category: Arnaout MA]]
[[Category: Essafi, M.]]
[[Category: Essafi M]]
[[Category: Li, R.]]
[[Category: Li R]]
[[Category: Stehle, T.]]
[[Category: Stehle T]]
[[Category: Xiong, J P.]]
[[Category: Xiong J-P]]
[[Category: A-domain]]
[[Category: Cd11b]]
[[Category: Cell adhesion protein]]
[[Category: Glycoprotein]]
[[Category: Integrin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:02:25 2008''
Retrieved from "https://proteopedia.org/1m1u"