1m4k: Difference between revisions

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{{Seed}}
[[Image:1m4k.png|left|200px]]


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==Crystal structure of the human natural killer cell activator receptor KIR2DS2 (CD158j)==
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<StructureSection load='1m4k' size='340' side='right'caption='[[1m4k]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4K FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1m4k|  PDB=1m4k  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4k OCA], [https://pdbe.org/1m4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4k RCSB], [https://www.ebi.ac.uk/pdbsum/1m4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KI2S2_HUMAN KI2S2_HUMAN] Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4k ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Killer cell Ig-like receptors (KIRs) regulate the function of human natural killer and T cell subsets. A feature of the KIR locus is the clustering of homologous genes encoding for inhibitory and activating KIR. Inhibitory and activating KIR differ for ligand specificities and/or affinities. In particular, we show here with KIR tetramers that activating KIR2DS2 does not bind HLA-Cw3 molecules recognized by inhibitory KIR2DL2, despite 99% extracellular amino acid identity. We also report the 2.3-A structure of KIR2DS2, which reveals subtle displacements of two residues (Tyr45 and Gln71) involved in the interaction of KIR2DL2 with HLA-Cw3. These results show that KIR molecules cannot tolerate any variability in their three-dimensional structure without altering their MHC class I recognition capacities. Therefore, the mode of recognition used by KIR largely differs from the conformational changes that characterize T cell receptor or NKG2D interaction with their respective ligands.


===Crystal structure of the human natural killer cell activator receptor KIR2DS2 (CD158j)===
Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j).,Saulquin X, Gastinel LN, Vivier E J Exp Med. 2003 Apr 7;197(7):933-8. Epub 2003 Mar 31. PMID:12668644<ref>PMID:12668644</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1m4k" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 12668644 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_12668644}}
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</StructureSection>
==About this Structure==
1M4K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4K OCA].
 
==Reference==
Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)., Saulquin X, Gastinel LN, Vivier E, J Exp Med. 2003 Apr 7;197(7):933-8. Epub 2003 Mar 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12668644 12668644]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Gastinel, L N.]]
[[Category: Gastinel LN]]
[[Category: Saulquin, X.]]
[[Category: Saulquin X]]
[[Category: Vivier, E.]]
[[Category: Vivier E]]
[[Category: Beta-sandwich]]
[[Category: Ig-like c2 type domain]]
 
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Retrieved from "https://proteopedia.org/1m4k"