1m5a: Difference between revisions

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{{Seed}}
[[Image:1m5a.png|left|200px]]


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==Crystal Structure of 2-Co(2+)-Insulin at 1.2A Resolution==
The line below this paragraph, containing "STRUCTURE_1m5a", creates the "Structure Box" on the page.
<StructureSection load='1m5a' size='340' side='right'caption='[[1m5a]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m5a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M5A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
{{STRUCTURE_1m5a| PDB=1m5a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m5a OCA], [https://pdbe.org/1m5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m5a RCSB], [https://www.ebi.ac.uk/pdbsum/1m5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m5a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m5/1m5a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m5a ConSurf].
<div style="clear:both"></div>


===Crystal Structure of 2-Co(2+)-Insulin at 1.2A Resolution===
==See Also==
 
*[[Insulin 3D Structures|Insulin 3D Structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1M5A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5A OCA].
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Korber, F C.]]
[[Category: Korber FC]]
[[Category: Nicholson, J M.]]
[[Category: Nicholson JM]]
[[Category: Perkins, L C.]]
[[Category: Perkins LC]]
[[Category: Alpha helice]]
[[Category: Beta sheet]]
[[Category: Disulphide bridge]]
 
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Retrieved from "https://proteopedia.org/1m5a"