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New page: left|200px<br /><applet load="1ifa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ifa, resolution 2.6Å" /> '''THREE-DIMENSIONAL CRY...
 
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[[Image:1ifa.jpg|left|200px]]<br /><applet load="1ifa" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ifa, resolution 2.6&Aring;" />
'''THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA'''<br />


==Overview==
==THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA==
The crystal structure of recombinant murine interferon-beta (IFN-beta) has, been solved by the multiple isomorphous replacement method and refined to, an R-factor of 20.5% against 2.6 A X-ray diffraction data. The structure, shows a variant of the alpha-helix bundle with a new chain-folding, topology, which seems to represent a basic structural framework of all the, IFN-alpha and IFN-beta molecules belonging to the type I family., Functionally important segments of the polypeptide chain, as implied, through numerous gene manipulation studies carried out so far, are, spatially clustered indicating the binding site(s) to the receptor(s)., Comparison of the present structure with those of other alpha-helical, cytokine proteins, including porcine growth hormone, interleukin 2 and, interferon gamma, indicated either a topological similarity in chain, folding or a similar spatial arrangement of the alpha-helices.
<StructureSection load='1ifa' size='340' side='right'caption='[[1ifa]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ifa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IFA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ifa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ifa OCA], [https://pdbe.org/1ifa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ifa RCSB], [https://www.ebi.ac.uk/pdbsum/1ifa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ifa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IFNB_MOUSE IFNB_MOUSE] Has antiviral, antibacterial and anticancer activities.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/1ifa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ifa ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1IFA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ASN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IFA OCA].
*[[Interferon 3D structures|Interferon 3D structures]]
 
*[[Multiple sclerosis|Multiple sclerosis]]
==Reference==
__TOC__
Three-dimensional crystal structure of recombinant murine interferon-beta., Senda T, Shimazu T, Matsuda S, Kawano G, Shimizu H, Nakamura KT, Mitsui Y, EMBO J. 1992 Sep;11(9):3193-201. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1505514 1505514]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Kawano G]]
[[Category: Kawano, G.]]
[[Category: Matsuda S]]
[[Category: Matsuda, S.]]
[[Category: Mitsui Y]]
[[Category: Mitsui, Y.]]
[[Category: Nakamura KT]]
[[Category: Nakamura, K.T.]]
[[Category: Senda T]]
[[Category: Senda, T.]]
[[Category: Shimizu H]]
[[Category: Shimizu, H.]]
[[Category: ASN]]
[[Category: glycoprotein]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:21:32 2007''

Latest revision as of 07:34, 7 February 2024

THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA

1ifa, resolution 2.60Å

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