1m8y: Difference between revisions

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{{Seed}}
[[Image:1m8y.png|left|200px]]


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==CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE2-10 RNA==
The line below this paragraph, containing "STRUCTURE_1m8y", creates the "Structure Box" on the page.
<StructureSection load='1m8y' size='340' side='right'caption='[[1m8y]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m8y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8Y FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8y OCA], [https://pdbe.org/1m8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8y RCSB], [https://www.ebi.ac.uk/pdbsum/1m8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8y ProSAT]</span></td></tr>
{{STRUCTURE_1m8y|  PDB=1m8y  |  SCENE=  }}
</table>
 
== Function ==
===CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE2-10 RNA===
[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_12202039}}, adds the Publication Abstract to the page
  <jmolCheckbox>
(as it appears on PubMed at http://www.pubmed.gov), where 12202039 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m8/1m8y_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_12202039}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m8y ConSurf].
1M8Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8Y OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
Modular recognition of RNA by a human pumilio-homology domain., Wang X, McLachlan J, Zamore PD, Hall TM, Cell. 2002 Aug 23;110(4):501-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12202039 12202039]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hall, T M.T.]]
[[Category: Hall TMT]]
[[Category: McLachlan, J.]]
[[Category: McLachlan J]]
[[Category: Wang, X.]]
[[Category: Wang X]]
[[Category: Zamore, P D.]]
[[Category: Zamore PD]]
[[Category: Nanos response element]]
[[Category: Puf domain]]
[[Category: Pumilio-homology domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:27:58 2008''
Retrieved from "https://proteopedia.org/1m8y"