1mna: Difference between revisions

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{{Seed}}
[[Image:1mna.png|left|200px]]


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==Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0==
The line below this paragraph, containing "STRUCTURE_1mna", creates the "Structure Box" on the page.
<StructureSection load='1mna' size='340' side='right'caption='[[1mna]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1mna]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MNA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mna OCA], [https://pdbe.org/1mna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mna RCSB], [https://www.ebi.ac.uk/pdbsum/1mna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mna ProSAT]</span></td></tr>
{{STRUCTURE_1mna|  PDB=1mna  |  SCENE=  }}
</table>
 
== Function ==
===Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0===
[https://www.uniprot.org/uniprot/PIKA4_STRVZ PIKA4_STRVZ] Involved in the biosynthesis of 12- and 14-membered ring macrolactone antibiotics such as methymycin and neomethymycin, and pikromycin and narbomycin, respectively. Component of the pikromycin PKS which catalyzes the biosynthesis of both precursors 10-deoxymethynolide (12-membered ring macrolactone) and narbonolide (14-membered ring macrolactone). Chain elongation through PikAI, PikAII and PikAIII followed by thioesterase catalyzed termination results in the production of 10-deoxymethynolide, while continued elongation through PikAIV, followed by thioesterase (TE) catalyzed cyclization results in the biosynthesis of the narbonolide. The thioesterase can use a series of diketide-N-acetylcysteamine (SNAC) thioesters, but has a strong preference for the 2-methyl-3-ketopentanoyl-SNAC over the stereoisomers of 2-methyl-3-hydroxyacyl-SNAC (PubMed:12379101, PubMed:12733905).<ref>PMID:10421766</ref> <ref>PMID:10676969</ref> <ref>PMID:12379101</ref> <ref>PMID:12733905</ref> <ref>PMID:16969372</ref> <ref>PMID:17719493</ref> <ref>PMID:19027305</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mn/1mna_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12379102}}
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mna ConSurf].
1MNA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNA OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases., Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM, Biochemistry. 2002 Oct 22;41(42):12598-606. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12379102 12379102]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces venezuelae]]
[[Category: Streptomyces venezuelae]]
[[Category: Cane, D E.]]
[[Category: Cane DE]]
[[Category: Khosla, C.]]
[[Category: Khosla C]]
[[Category: Lu, H.]]
[[Category: Lu H]]
[[Category: Stroud, R M.]]
[[Category: Stroud RM]]
[[Category: Tsai, S C.]]
[[Category: Tsai S-C]]
[[Category: Alpha-beta hydrolase]]
[[Category: Open substrate channel]]
[[Category: Polyketide synthase]]
[[Category: Thioesterase]]
 
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Retrieved from "https://proteopedia.org/1mna"