1mnp: Difference between revisions

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{{Seed}}
[[Image:1mnp.png|left|200px]]


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==MANGANESE PEROXIDASE==
The line below this paragraph, containing "STRUCTURE_1mnp", creates the "Structure Box" on the page.
<StructureSection load='1mnp' size='340' side='right'caption='[[1mnp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1mnp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phanerodontia_chrysosporium Phanerodontia chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MNP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
{{STRUCTURE_1mnp|  PDB=1mnp  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mnp OCA], [https://pdbe.org/1mnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mnp RCSB], [https://www.ebi.ac.uk/pdbsum/1mnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mnp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PEM1_PHACH PEM1_PHACH] Catalyzes the oxidation of Mn(2+) to Mn(3+). The latter, acting as a diffusible redox mediator, is capable of oxidizing a variety of lignin compounds.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mn/1mnp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mnp ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Manganese peroxidase from the white rot basidiomycete Phanerochaete chrysosporium has been crystallized in a form suitable for high-resolution X-ray structure determination. Crystals were grown from solutions containing 30% polyethylene glycol 8000, ammonium sulfate and cacodylate buffer at pH 6.5, using macroseeding techniques. A complete data set has been obtained to 2.06 A resolution. The data can be indexed in space group P1 with a = 45.96 A, b = 53.77 A, c = 84.87 A, alpha = 97.01 degrees, beta = 105.72 degrees and gamma = 90.1 degrees, with two peroxidase molecules per asymmetric unit, or in space group C2 with a = 163.23 A, b = 45.97 A, c = 53.72 A and beta = 97.16 degrees, with only one molecule in the assymetric unit. Lignin peroxidase, which shares about 57% sequence identity with manganese peroxidase, was used as a probe for molecular replacement. Unique rotation and translation solutions have been obtained in space groups P1 and C2. The structure has been partially refined in space group C2 to R = 0.22 for data between 10 and 2.06 A.


===MANGANESE PEROXIDASE===
Preliminary crystallographic analysis of manganese peroxidase from Phanerochaete chrysosporium.,Sundaramoorthy M, Kishi K, Gold MH, Poulos TL J Mol Biol. 1994 May 20;238(5):845-8. PMID:8182752<ref>PMID:8182752</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1mnp" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_8182752}}, adds the Publication Abstract to the page
*[[Manganese peroxidase|Manganese peroxidase]]
(as it appears on PubMed at http://www.pubmed.gov), where 8182752 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_8182752}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1MNP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phanerochaete_chrysosporium Phanerochaete chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNP OCA].
[[Category: Phanerodontia chrysosporium]]
 
[[Category: Poulos TL]]
==Reference==
[[Category: Sundaramoorthy M]]
Preliminary crystallographic analysis of manganese peroxidase from Phanerochaete chrysosporium., Sundaramoorthy M, Kishi K, Gold MH, Poulos TL, J Mol Biol. 1994 May 20;238(5):845-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8182752 8182752]
[[Category: Peroxidase]]
[[Category: Phanerochaete chrysosporium]]
[[Category: Single protein]]
[[Category: Poulos, T L.]]
[[Category: Sundaramoorthy, M.]]
[[Category: Heme peroxidase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:29:23 2008''

Latest revision as of 06:39, 13 August 2026

MANGANESE PEROXIDASE

1mnp, resolution 2.00Å

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