3bxu: Difference between revisions

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{{Seed}}
[[Image:3bxu.jpg|left|200px]]


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==PpcB, A Cytochrome c7 from Geobacter sulfurreducens==
The line below this paragraph, containing "STRUCTURE_3bxu", creates the "Structure Box" on the page.
<StructureSection load='3bxu' size='340' side='right'caption='[[3bxu]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bxu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BXU FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3bxu|  PDB=3bxu  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bxu OCA], [https://pdbe.org/3bxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bxu RCSB], [https://www.ebi.ac.uk/pdbsum/3bxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bxu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q74G83_GEOSL Q74G83_GEOSL]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/3bxu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bxu ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The redox properties of a periplasmic triheme cytochrome, PpcB from Geobacter sulfurreducens, were studied by NMR and visible spectroscopy. The structure of PpcB was determined by X-ray diffraction. PpcB is homologous to PpcA (77% sequence identity), which mediates cytoplasmic electron transfer to extracellular acceptors and is crucial in the bioenergetic metabolism of Geobacter spp. The heme core structure of PpcB in solution, probed by 2D-NMR, was compared to that of PpcA. The results showed that the heme core structures of PpcB and PpcA in solution are similar, in contrast to their crystal structures where the heme cores of the two proteins differ from each other. NMR redox titrations were carried out for both proteins and the order of oxidation of the heme groups was determined. The microscopic properties of PpcB and PpcA redox centers showed important differences: (i) the order in which hemes become oxidized is III-I-IV for PpcB, as opposed to I-IV-III for PpcA; (ii) the redox-Bohr effect is also different in the two proteins. The different redox features observed between PpcB and PpcA suggest that each protein uniquely modulates the properties of their co-factors to assure effectiveness in their respective metabolic pathways. The origins of the observed differences are discussed.


===PpcB, A Cytochrome c7 from Geobacter sulfurreducens===
Structural insights into the modulation of the redox properties of two Geobacter sulfurreducens homologous triheme cytochromes.,Morgado L, Bruix M, Orshonsky V, Londer YY, Duke NE, Yang X, Pokkuluri PR, Schiffer M, Salgueiro CA Biochim Biophys Acta. 2008 Sep;1777(9):1157-65. Epub 2008 May 9. PMID:18534185<ref>PMID:18534185</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3bxu" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_18534185}}, adds the Publication Abstract to the page
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18534185 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_18534185}}
__TOC__
 
</StructureSection>
==About this Structure==
3BXU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BXU OCA].
 
==Reference==
Structural insights into the modulation of the redox properties of two Geobacter sulfurreducens homologous triheme cytochromes., Morgado L, Bruix M, Orshonsky V, Londer YY, Duke NE, Yang X, Pokkuluri PR, Schiffer M, Salgueiro CA, Biochim Biophys Acta. 2008 May 9;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18534185 18534185]
[[Category: Geobacter sulfurreducens]]
[[Category: Geobacter sulfurreducens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Pokkuluri, P R.]]
[[Category: Pokkuluri PR]]
[[Category: Schiffer, M.]]
[[Category: Schiffer M]]
[[Category: Cytochrome c7 geobacter sulfurreducen]]
[[Category: Electron transport]]
[[Category: Multiheme cytochrome]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 11:27:20 2008''

Latest revision as of 08:59, 13 August 2026

PpcB, A Cytochrome c7 from Geobacter sulfurreducens

3bxu, resolution 1.35Å

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