1ipg: Difference between revisions
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New page: left|200px<br /><applet load="1ipg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ipg" /> '''SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1... |
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== | ==SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P== | ||
PB1 domains are novel protein modules capable of binding to target | <StructureSection load='1ipg' size='340' side='right'caption='[[1ipg]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1ipg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IPG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ipg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ipg OCA], [https://pdbe.org/1ipg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ipg RCSB], [https://www.ebi.ac.uk/pdbsum/1ipg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ipg ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BEM1_YEAST BEM1_YEAST] Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface.<ref>PMID:17460121</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/1ipg_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ipg ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
PB1 domains are novel protein modules capable of binding to target proteins that contain PC motifs. We report here the NMR structure and ligand-binding site of the PB1 domain of the cell polarity establishment protein, Bem1p. In addition, we identify the topology of the PC motif-containing region of Cdc24p by NMR, another cell polarity establishment protein that interacts with Bem1p. The PC motif-containing region is a structural domain offering a scaffold to the PC motif. The chemical shift perturbation experiment and the mutagenesis study show that the PC motif is a major structural element that binds to the PB1 domain. A structural database search reveals close similarity between the Bem1p PB1 domain and the c-Raf1 Ras-binding domain. However, these domains are functionally distinct from each other. | |||
Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif.,Terasawa H, Noda Y, Ito T, Hatanaka H, Ichikawa S, Ogura K, Sumimoto H, Inagaki F EMBO J. 2001 Aug 1;20(15):3947-56. PMID:11483498<ref>PMID:11483498</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1ipg" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Hatanaka H]] | |||
[[Category: Hatanaka | [[Category: Ichikawa S]] | ||
[[Category: Ichikawa | [[Category: Inagaki F]] | ||
[[Category: Inagaki | [[Category: Ito T]] | ||
[[Category: Ito | [[Category: Noda Y]] | ||
[[Category: Noda | [[Category: Ogura K]] | ||
[[Category: Ogura | [[Category: Sumimoto H]] | ||
[[Category: Sumimoto | [[Category: Terasawa H]] | ||
[[Category: Terasawa | |||
Latest revision as of 23:34, 27 December 2023
SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P
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