1mr0: Difference between revisions

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{{Seed}}
[[Image:1mr0.png|left|200px]]


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==SOLUTION NMR STRUCTURE OF AGRP(87-120; C105A)==
The line below this paragraph, containing "STRUCTURE_1mr0", creates the "Structure Box" on the page.
<StructureSection load='1mr0' size='340' side='right'caption='[[1mr0]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1mr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mc6 1mc6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MR0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr0 OCA], [https://pdbe.org/1mr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mr0 RCSB], [https://www.ebi.ac.uk/pdbsum/1mr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mr0 ProSAT]</span></td></tr>
{{STRUCTURE_1mr0|  PDB=1mr0  |  SCENE=  }}
</table>
 
== Disease ==
===SOLUTION NMR STRUCTURE OF AGRP(87-120; C105A)===
[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:12213871</ref>
 
== Function ==
 
[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.<ref>PMID:9892020</ref> <ref>PMID:11145747</ref> <ref>PMID:17041250</ref> <ref>PMID:10371151</ref> <ref>PMID:15927146</ref>
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== Evolutionary Conservation ==
The line below this paragraph, {{ABSTRACT_PUBMED_12056887}}, adds the Publication Abstract to the page
[[Image:Consurf_key_small.gif|200px|right]]
(as it appears on PubMed at http://www.pubmed.gov), where 12056887 is the PubMed ID number.
Check<jmol>
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  <jmolCheckbox>
{{ABSTRACT_PUBMED_12056887}}
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mr0_consurf.spt"</scriptWhenChecked>
 
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
==About this Structure==
    <text>to colour the structure by Evolutionary Conservation</text>
1MR0 is a [[Single protein]] structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mc6 1mc6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR0 OCA].  
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mr0 ConSurf].
==Reference==
<div style="clear:both"></div>
Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity., Jackson PJ, McNulty JC, Yang YK, Thompson DA, Chai B, Gantz I, Barsh GS, Millhauser GL, Biochemistry. 2002 Jun 18;41(24):7565-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12056887 12056887]
== References ==
[[Category: Single protein]]
<references/>
[[Category: Barsh, G S.]]
__TOC__
[[Category: Chai, B.]]
</StructureSection>
[[Category: Gantz, I.]]
[[Category: Homo sapiens]]
[[Category: Jackson, P J.]]
[[Category: Large Structures]]
[[Category: Mcnulty, J C.]]
[[Category: Barsh GS]]
[[Category: Millhauser, G M.]]
[[Category: Chai B]]
[[Category: Thompson, D A.]]
[[Category: Gantz I]]
[[Category: Yang, Y K.]]
[[Category: Jackson PJ]]
[[Category: Agouti-related protein]]
[[Category: Mcnulty JC]]
[[Category: Agrp]]
[[Category: Millhauser GM]]
[[Category: Ick]]
[[Category: Thompson DA]]
[[Category: Inhibitor cystine knot]]
[[Category: Yang YK]]
[[Category: Melanocortin]]
[[Category: Rational protein design]]
 
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Retrieved from "https://proteopedia.org/1mr0"