2okn: Difference between revisions

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{{Seed}}
[[Image:2okn.png|left|200px]]


<!--
==Crystal Strcture of Human Prolidase==
The line below this paragraph, containing "STRUCTURE_2okn", creates the "Structure Box" on the page.
<StructureSection load='2okn' size='340' side='right'caption='[[2okn]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2okn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OKN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PI:HYDROGENPHOSPHATE+ION'>PI</scene></td></tr>
{{STRUCTURE_2okn|  PDB=2okn  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2okn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2okn OCA], [https://pdbe.org/2okn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2okn RCSB], [https://www.ebi.ac.uk/pdbsum/2okn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2okn ProSAT]</span></td></tr>
 
</table>
===Crystal Strcture of Human Prolidase===
== Disease ==
 
[https://www.uniprot.org/uniprot/PEPD_HUMAN PEPD_HUMAN] Defects in PEPD are a cause of prolidase deficiency (PD) [MIM:[https://omim.org/entry/170100 170100]. Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait.<ref>PMID:2365824</ref> <ref>PMID:8198124</ref> <ref>PMID:8900231</ref> <ref>PMID:12384772</ref>
 
== Function ==
==About this Structure==
[https://www.uniprot.org/uniprot/PEPD_HUMAN PEPD_HUMAN] Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
2OKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKN OCA].  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/2okn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2okn ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Xaa-Pro dipeptidase]]
[[Category: Behlke J]]
[[Category: Behlke, J.]]
[[Category: Buessow K]]
[[Category: Buessow, K.]]
[[Category: Goetz F]]
[[Category: Goetz, F.]]
[[Category: Heinemann U]]
[[Category: Heinemann, U.]]
[[Category: Mueller U]]
[[Category: Mueller, U.]]
[[Category: Niesen FH]]
[[Category: Niesen, F H.]]
[[Category: Roske Y]]
[[Category: PSF, Protein Structure Factory.]]
[[Category: Roske, Y.]]
[[Category: Acetylation]]
[[Category: Collagen degradation]]
[[Category: Dipeptidase]]
[[Category: Disease mutation]]
[[Category: Enzyme]]
[[Category: Hydrolase]]
[[Category: Manganese]]
[[Category: Metal-binding]]
[[Category: Metalloaminopeptidase]]
[[Category: Metallocarboxypeptidase]]
[[Category: Metalloprotease]]
[[Category: Pepd gene]]
[[Category: Peptidase d]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protein structure factory]]
[[Category: Psf]]
[[Category: Structural genomic]]
[[Category: Xaa-pro dipeptidase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul  6 00:58:50 2008''
Retrieved from "https://proteopedia.org/2okn"