2ex5: Difference between revisions

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{{Seed}}
[[Image:2ex5.png|left|200px]]


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==Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA==
The line below this paragraph, containing "STRUCTURE_2ex5", creates the "Structure Box" on the page.
<StructureSection load='2ex5' size='340' side='right'caption='[[2ex5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ex5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_moewusii Chlamydomonas moewusii] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EX5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_2ex5| PDB=2ex5 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ex5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ex5 OCA], [https://pdbe.org/2ex5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ex5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ex5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ex5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNE1_CHLMO DNE1_CHLMO] Endonuclease involved in intron homing. Recognizes a degenerate sequence of 17-19 bp to produce a staggered cut 5 bp downstream from the CeLSU.5 intron insertion site.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2ex5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ex5 ConSurf].
<div style="clear:both"></div>


===Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA===
==See Also==
 
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_16698548}}, adds the Publication Abstract to the page
[[Category: Chlamydomonas moewusii]]
(as it appears on PubMed at http://www.pubmed.gov), where 16698548 is the PubMed ID number.
[[Category: Large Structures]]
-->
[[Category: Synthetic construct]]
{{ABSTRACT_PUBMED_16698548}}
[[Category: Spiegel PC]]
 
[[Category: Stoddard BL]]
==About this Structure==
2EX5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_eugametos Chlamydomonas eugametos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EX5 OCA].
 
==Reference==
The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold., Spiegel PC, Chevalier B, Sussman D, Turmel M, Lemieux C, Stoddard BL, Structure. 2006 May;14(5):869-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16698548 16698548]
[[Category: Chlamydomonas eugametos]]
[[Category: Single protein]]
[[Category: Spiegel, P C.]]
[[Category: Stoddard, B L.]]
[[Category: Homing endonuclease]]
[[Category: Homodimer]]
[[Category: Laglidadg]]
[[Category: Protein/dna complex]]
 
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Retrieved from "https://proteopedia.org/2ex5"