2vwi: Difference between revisions

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[[Image:2vwi.jpg|left|200px]]


<!--
==Structure of the OSR1 kinase, a hypertension drug target==
The line below this paragraph, containing "STRUCTURE_2vwi", creates the "Structure Box" on the page.
<StructureSection load='2vwi' size='340' side='right'caption='[[2vwi]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2vwi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VWI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2vwi|  PDB=2vwi |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwi OCA], [https://pdbe.org/2vwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vwi RCSB], [https://www.ebi.ac.uk/pdbsum/2vwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vwi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OXSR1_HUMAN OXSR1_HUMAN] Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.<ref>PMID:14707132</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/2vwi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vwi ConSurf].
<div style="clear:both"></div>


===STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET===
==See Also==
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2VWI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWI OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Alessi DR]]
[[Category: Alessi, D R.]]
[[Category: Deak M]]
[[Category: Deak, M.]]
[[Category: Villa F]]
[[Category: Vanaalten, D M.F.]]
[[Category: VanAalten DMF]]
[[Category: Villa, F.]]
[[Category: Hypertension]]
[[Category: Kinase]]
[[Category: Ste kinase]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  9 10:42:08 2008''

Latest revision as of 10:05, 9 May 2024

Structure of the OSR1 kinase, a hypertension drug target

2vwi, resolution 2.15Å

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