Chitinase: Difference between revisions
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New page: ==This is a placeholder== Chitinases cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria a... |
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== | <StructureSection load='3wh1' size='350' side='right' caption='Chitinase A complex with (GlcNac)4 and ethylene glycol (PDB entry [[3wh1]])' scene='27/271631/Cv/3'> | ||
__TOC__ | |||
== Function == | |||
[[Chitinase]]s (Chi) cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>. <br /> | |||
* '''Chitinase I''' is found in plants.<br /> | |||
* '''Chitinase II''' is found in plants, fungi and bacteria.<br /> | |||
* '''Chitinase III''' has no sequence similarity to class I or II.<br /> | |||
* '''Chitinase IV''' has similar characteristics to class I but are smaller than it.<br /> | |||
The | ==Disease == | ||
Chi is related to allergies and asthma<ref>PMID:19295241</ref>. | |||
== Structural highlights == | |||
The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A. <ref>PMID:24582745</ref> Water molecules are shown as red spheres. | |||
== 3D Structures of Chitinase == | |||
[[Chitinase 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
Latest revision as of 09:45, 8 May 2019
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References
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, Anastassis Perrakis, Marcin Jozef Suskiewicz, Michal Harel
