2jjc: Difference between revisions

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{{Seed}}
[[Image:2jjc.png|left|200px]]


<!--
==Hsp90 alpha ATPase domain with bound small molecule fragment==
The line below this paragraph, containing "STRUCTURE_2jjc", creates the "Structure Box" on the page.
<StructureSection load='2jjc' size='340' side='right'caption='[[2jjc]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JJC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LGA:PYRIMIDIN-2-AMINE'>LGA</scene></td></tr>
{{STRUCTURE_2jjc| PDB=2jjc |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jjc OCA], [https://pdbe.org/2jjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jjc RCSB], [https://www.ebi.ac.uk/pdbsum/2jjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jjc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jj/2jjc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jjc ConSurf].
<div style="clear:both"></div>


===HSP90 ALPHA ATPASE DOMAIN WITH BOUND SMALL MOLECULE FRAGMENT===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
==About this Structure==
<references/>
2JJC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJC OCA].
__TOC__
 
</StructureSection>
==Reference==
Recent developments in fragment-based drug discovery., Congreve M, Chessari G, Tisi D, Woodhead AJ, J Med Chem. 2008 Jul 10;51(13):3661-80. Epub 2008 May 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18457385 18457385]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Chessari, G.]]
[[Category: Chessari G]]
[[Category: Congreve, M.]]
[[Category: Congreve M]]
[[Category: Tisi, D.]]
[[Category: Tisi D]]
[[Category: Woodhead, A J.]]
[[Category: Woodhead AJ]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atpase]]
[[Category: Chaperone]]
[[Category: Cytoplasm]]
[[Category: Heat shock]]
[[Category: Hsp90]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:08:53 2008''
Retrieved from "https://proteopedia.org/2jjc"