1jfi: Difference between revisions

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{{Seed}}
[[Image:1jfi.png|left|200px]]


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==Crystal Structure of the NC2-TBP-DNA Ternary Complex==
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<StructureSection load='1jfi' size='340' side='right'caption='[[1jfi]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jfi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The July 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''TATA-Binding Protein''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_7 10.2210/rcsb_pdb/mom_2005_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfi OCA], [https://pdbe.org/1jfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfi RCSB], [https://www.ebi.ac.uk/pdbsum/1jfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfi ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1jfi TOPSAN]</span></td></tr>
{{STRUCTURE_1jfi|  PDB=1jfi  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/NC2A_HUMAN NC2A_HUMAN] The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.<ref>PMID:8670811</ref> <ref>PMID:8608938</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfi ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The X-ray structure of a ternary complex of Negative Cofactor 2 (NC2), the TATA box binding protein (TBP), and DNA has been determined at 2.6 A resolution. The N termini of NC2 alpha and beta resemble histones H2A and H2B, respectively, and form a heterodimer that binds to the bent DNA double helix on the underside of the preformed TBP-DNA complex via electrostatic interactions. NC2beta contributes to inhibition of TATA-dependent transcription through interactions of its C-terminal alpha helix with a conserved hydrophobic feature on the upper surface of TBP, which in turn positions the penultimate alpha helix of NC2beta to block recognition of the TBP-DNA complex by transcription factor IIB. Further regulatory implications of the NC2 heterodimer structure are discussed.


===Crystal Structure of the NC2-TBP-DNA Ternary Complex===
Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.,Kamada K, Shu F, Chen H, Malik S, Stelzer G, Roeder RG, Meisterernst M, Burley SK Cell. 2001 Jul 13;106(1):71-81. PMID:11461703<ref>PMID:11461703</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1jfi" style="background-color:#fffaf0;"></div>


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==See Also==
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*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 11461703 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_11461703}}
__TOC__
 
</StructureSection>
==About this Structure==
1JFI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Additional information on 1JFI is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFI OCA].
 
==Reference==
Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex., Kamada K, Shu F, Chen H, Malik S, Stelzer G, Roeder RG, Meisterernst M, Burley SK, Cell. 2001 Jul 13;106(1):71-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11461703 11461703]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: TATA-Binding Protein]]
[[Category: TATA-Binding Protein]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Chen, H.]]
[[Category: Chen H]]
[[Category: Kamada, K.]]
[[Category: Kamada K]]
[[Category: Malik, S.]]
[[Category: Malik S]]
[[Category: Meisterernst, M.]]
[[Category: Meisterernst M]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Roeder RG]]
[[Category: Roeder, R G.]]
[[Category: Shu F]]
[[Category: Shu, F.]]
[[Category: Stelzer G]]
[[Category: Stelzer, G.]]
[[Category: H2a/h2b]]
[[Category: Histone]]
[[Category: Nc2]]
[[Category: Negative cofactor]]
[[Category: New york structural genomix research consortium]]
[[Category: Nysgxrc]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Tata-dna]]
[[Category: Tbp]]
[[Category: Transcription initiation]]
 
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