1ig8: Difference between revisions

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{{Seed}}
[[Image:1ig8.png|left|200px]]


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==Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence==
The line below this paragraph, containing "STRUCTURE_1ig8", creates the "Structure Box" on the page.
<StructureSection load='1ig8' size='340' side='right'caption='[[1ig8]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ig8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The February 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''The Glycolytic Enzymes''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_2 10.2210/rcsb_pdb/mom_2004_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IG8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1ig8|  PDB=1ig8 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ig8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig8 OCA], [https://pdbe.org/1ig8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ig8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ig8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ig8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HXKB_YEAST HXKB_YEAST] Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/1ig8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ig8 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence===
==See Also==
 
*[[Hexokinase 3D structures|Hexokinase 3D structures]]
 
__TOC__
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
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{{ABSTRACT_PUBMED_10749890}}
 
==About this Structure==
1IG8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Additional information on 1IG8 is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb50_1.html The Glycolytic Enzymes] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG8 OCA].
 
==Reference==
The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action., Kuser PR, Krauchenco S, Antunes OA, Polikarpov I, J Biol Chem. 2000 Jul 7;275(27):20814-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10749890 10749890]
[[Category: Hexokinase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: The Glycolytic Enzymes]]
[[Category: The Glycolytic Enzymes]]
[[Category: Antunes, O A.]]
[[Category: Antunes OA]]
[[Category: Krauchenco, S.]]
[[Category: Krauchenco S]]
[[Category: Kuser, P R.]]
[[Category: Kuser PR]]
[[Category: Polikarpov, I.]]
[[Category: Polikarpov I]]
[[Category: Cleft]]
[[Category: Mixed alpha beta]]
[[Category: Two domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:14:30 2008''
Retrieved from "https://proteopedia.org/1ig8"