1fv4: Difference between revisions
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New page: '''Theoretical Model''' The entry 1FV4 is a Theoretical Model titled 'THREE DIMENSIONAL MODEL OF COAGULATION FACTOR VA'. Category:Theoretical Model ''Page seeded by [http://oca.wei... |
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{{Theoretical_model}} | |||
==THREE DIMENSIONAL MODEL OF COAGULATION FACTOR VA== | |||
<StructureSection load='1fv4' size='340' side='right'caption='[[1fv4]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FV4 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fv4 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1fv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv4 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A complete molecular model of blood coagulation factor Va (FVa) bound to anticoagulant activated protein C (APC) and to a phospholipid membrane was constructed. The three homologous A domains and the two homologous C domains of FVA were modeled based on the X-ray crystallographic structures of ceruloplasmin and C2 domain of factor V, respectively. The final arrangement of the five domains in the complete FVa model bound to a membrane incorporated extensive published experimental data. FVa binds the phospholipid membrane through its C2 domain while the A-domain trimer is located from 40 through 100 A above the membrane plane. From our model we infer a probable role for metal ions at the interface between FVa light and heavy chains, provide an explanation for the slower APC cleavage at Arg306 relative to Arg506, and predict specific interactions between positively and negatively charged exosites in APC and FVa, respectively. | |||
Three-dimensional model of coagulation factor Va bound to activated protein C.,Pellequer JL, Gale AJ, Getzoff ED, Griffin JH Thromb Haemost. 2000 Nov;84(5):849-57. PMID:11127867<ref>PMID:11127867</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1fv4" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Pellequer, J.-L]] | |||
Latest revision as of 11:15, 28 July 2021
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THREE DIMENSIONAL MODEL OF COAGULATION FACTOR VA
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