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New page: '''Theoretical Model''' The entry 1HLH is a Theoretical Model titled 'PROPOSED STRUCTURE FOR THE DNA-BINDING DOMAIN OF THE HELIX-LOOP-HELIX FAMILY OF EUKARYOTIC GENE REGULATORY PROTEINS'.... |
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{{Theoretical_model}} | |||
==PROPOSED STRUCTURE FOR THE DNA-BINDING DOMAIN OF THE HELIX- LOOP-HELIX FAMILY OF EUKARYOTIC GENE REGULATORY PROTEINS== | |||
<StructureSection load='1hlh' size='340' side='right'caption='[[1hlh]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLH FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hlh FirstGlance], [https://www.ebi.ac.uk/pdbsum/1hlh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hlh ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A modelled tertiary structure for the dimeric HLH domain of the E47 protein is presented. Structural information was obtained from the aligned sequences of > 40 members of the HLH family. The information was used to model each monomer as an alpha-helical hairpin, with knobs-into-holes packing of side-chains as found in antiparallel coiled-coil. The dimer forms a four-helix bundle with additional knobs-into-holes packing at the dimer interface. The size and electrostatic properties of core-forming residues are all accounted for in the model. The model does not violate any known properties of protein structure. The monomers are related by two-fold rotational symmetry, in agreement with the observed DNA-binding sites which are imperfect inverted repeats. The N-terminal basic region, in which DNA binding and base specificity reside, forms the first part of helix 1. A prediction based on the model structure is that the HLH domains do not bind to DNA in its B form but require a partially unwound conformation in order to enter the major groove. | |||
Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins.,Gibson TJ, Thompson JD, Abagyan RA Protein Eng. 1993 Jan;6(1):41-50. PMID:8433970<ref>PMID:8433970</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1hlh" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Abagyan, R A]] | |||
[[Category: Gibson, T J]] | |||
[[Category: Thompson, J D]] | |||
Latest revision as of 10:50, 4 August 2021
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PROPOSED STRUCTURE FOR THE DNA-BINDING DOMAIN OF THE HELIX- LOOP-HELIX FAMILY OF EUKARYOTIC GENE REGULATORY PROTEINS
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