1hvp: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Theoretical Model''' The entry 1HVP is a Theoretical Model titled 'MOLECULAR MODELING OF THE HIV-1 PROTEASE AND ITS SUBSTRATE BINDING SITE'. Category:Theoretical Model ''Page se... |
No edit summary |
||
| (10 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{Theoretical_model}} | |||
==MOLECULAR MODELING OF THE HIV-1 PROTEASE AND ITS SUBSTRATE BINDING SITE== | |||
<StructureSection load='1hvp' size='340' side='right'caption='[[1hvp]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HVP FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hvp FirstGlance], [https://www.ebi.ac.uk/pdbsum/1hvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hvp ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The human immunodeficiency virus (HIV-1) encodes a protease that is essential for viral replication and is a member of the aspartic protease family. The recently determined three-dimensional structure of the related protease from Rous sarcoma virus has been used to model the smaller HIV-1 dimer. The active site has been analyzed by comparison to the structure of the aspartic protease, rhizopuspepsin, complexed with a peptide inhibitor. The HIV-1 protease is predicted to interact with seven residues of the protein substrate. This information can be used to design protease inhibitors and possible antiviral drugs. | |||
Molecular modeling of the HIV-1 protease and its substrate binding site.,Weber IT, Miller M, Jaskolski M, Leis J, Skalka AM, Wlodawer A Science. 1989 Feb 17;243(4893):928-31. PMID:2537531<ref>PMID:2537531</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1hvp" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Weber, I T]] | |||
Latest revision as of 10:54, 4 August 2021
 |
MOLECULAR MODELING OF THE HIV-1 PROTEASE AND ITS SUBSTRATE BINDING SITE
| ||||||||||||
