1bai: Difference between revisions
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New page: left|200px<br /> <applet load="1bai" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bai, resolution 2.4Å" /> '''STRUCTURAL BASIS FOR... |
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== | ==Crystal structure of Rous sarcoma virus protease in complex with inhibitor== | ||
<StructureSection load='1bai' size='340' side='right'caption='[[1bai]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1bai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q4:N-[(2R)-2-({N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHYL-L-VALYL}AMINO)-4-METHYLPENTYL]-L-PHENYLALANYL-L-ALPHA-GLUTAMYL-L-ALANYL-L-NORLEUCINAMIDE'>0Q4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bai OCA], [https://pdbe.org/1bai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bai RCSB], [https://www.ebi.ac.uk/pdbsum/1bai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bai ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/1bai_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bai ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Virus protease 3D structures|Virus protease 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rous sarcoma virus]] | [[Category: Rous sarcoma virus]] | ||
[[Category: Adomat JM]] | |||
[[Category: Adomat | [[Category: Harrison RW]] | ||
[[Category: Harrison | [[Category: Leis J]] | ||
[[Category: Leis | [[Category: Louis JM]] | ||
[[Category: Louis | [[Category: Ridky TW]] | ||
[[Category: Ridky | [[Category: Weber IT]] | ||
[[Category: Weber | [[Category: Wu J]] | ||
[[Category: Wu | |||
Latest revision as of 06:34, 7 February 2024
Crystal structure of Rous sarcoma virus protease in complex with inhibitor
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