1wkn: Difference between revisions
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New page: '''Theoretical Model''' The entry 1WKN is a Theoretical Model titled 'A plausible model of full-length integraseDNA complex'. Category:Theoretical Model ''Page seeded by [http://oc... |
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{{Theoretical_model}} | |||
==A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX== | |||
<StructureSection load='1wkn' size='340' side='right'caption='[[1wkn]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKN FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkn FirstGlance], [https://www.ebi.ac.uk/pdbsum/1wkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkn ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A model of the full-length HIV-1 integrase dimer was constructed assembling the experimentally determined structures of the single domains. Subsequently, the three-domain protein-viral DNA complex was generated for the first time through an automated docking algorithm, obtained modifying the ESCHER program, a well-known method for protein-protein docking. A detailed study of the contacts established with DNA by the enzyme revealed that the predicted model reproduced the results of mutagenesis and cross-linking experiments, confirming the validity of our docking approach in predicting the base specificity in the DNA-protein interaction. | |||
Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking.,De Luca L, Pedretti A, Vistoli G, Barreca ML, Villa L, Monforte P, Chimirri A Biochem Biophys Res Commun. 2003 Oct 31;310(4):1083-8. PMID:14559226<ref>PMID:14559226</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1wkn" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Barreca, M L]] | |||
[[Category: Chimirri, A]] | |||
[[Category: De Luca, L]] | |||
[[Category: Monforte, P]] | |||
[[Category: Pedretti, A]] | |||
[[Category: Villa, L]] | |||
[[Category: Vistoli, G]] | |||
Latest revision as of 16:20, 27 October 2021
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A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX
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