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New page: '''Theoretical Model''' The entry 2PSK is a Theoretical Model titled 'THEORETICAL MODEL OF AN FAB FRAGMENT COMPLEXED WITH THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE'. [[Category:Theoretical... |
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{{Theoretical_model}} | |||
==THEORETICAL MODEL OF AN FAB FRAGMENT COMPLEXED WITH THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE== | |||
<StructureSection load='2psk' size='340' side='right'caption='[[2psk]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PSK FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2psk FirstGlance], [https://www.ebi.ac.uk/pdbsum/2psk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2psk ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The GD2 ganglioside is a cell-surface component that appears on the surface of metastatic melanoma cells and is a marker for the progression of the disease. The ME36.1 monoclonal antibody binds to the GD2 ganglioside and has shown potential as a therapeutic antibody. ME36.1 is a possible alternative therapy to radiation, which is often ineffective in late-stage melanoma. The crystal structure of the Fab fragment of ME36.1 has been determined using molecular replacement and refined to an R factor of 20.4% at 2.8 A resolution. The model has good geometry with root-mean-square deviations of 0.008 A from ideal bond lengths and 1.7 degrees from ideal bond angles. The crystal structure of the ME36.1 Fab shows that its complementarity determining region forms a groove-shaped binding site rather than the pocket-type observed in other sugar binding Fabs. Molecular modeling has placed a four-residue sugar, representative of GD2, in the antigen binding site. The GD2 sugar moiety is stabilized by a network of hydrogen bonds that define the specificity of ME36.1 toward its antigen. | |||
The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside.,Pichla SL, Murali R, Burnett RM J Struct Biol. 1997 Jun;119(1):6-16. PMID:9216084<ref>PMID:9216084</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2psk" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Burnett, R M]] | |||
[[Category: Murali, R]] | |||
[[Category: Pichla, S L]] | |||
Latest revision as of 07:47, 9 March 2022
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THEORETICAL MODEL OF AN FAB FRAGMENT COMPLEXED WITH THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE
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